Anti-Human CANT1 Antibody Pair

Product Description: Calcium Activated Nucleotidase 1 (CANT1) is an enzyme encoded by the CANT1 gene located on chromosome 17q25.3 in humans. It is a soluble calcium-activated nucleotidase with a preference for UDP over other nucleotides like GDP, UTP, and GTP, and it has very low activity towards ADP and ATP. CANT1 is involved in proteoglycan synthesis and has been implicated in various diseases. Mutations in the CANT1 gene are associated with Desbuquois dysplasia, a rare skeletal disorder. Additionally, CANT1 has been found to be overexpressed in prostate cancer and plays a role in cell proliferation, migration, and invasion. The protein has a molecular weight of 44,839.24 Da and a theoretical pI of 6.082, with 401 residues. Protein Function: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15006348, PubMed:15248776, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336) [The Uniprot Consortium]