Anti-Human BMPR1B Antibody Pair

Product Description: Bone Morphogenetic Protein Receptor Type 1B (BMPR1B) is a transmembrane serine/threonine kinase receptor that plays a crucial role in the bone morphogenetic protein (BMP) signaling pathway. It is involved in various biological processes, including embryogenesis, tissue homeostasis, and disease progression. BMPR1B is predominantly expressed in embryonic tissues, skeletal structures, and reproductive organs, and it signals through Smad-dependent and Smad-independent pathways to regulate gene expression, cellular proliferation, differentiation, and apoptosis. Mutations in the BMPR1B gene have been associated with several diseases, including acromesomelic dysplasia, brachydactyly type A1, and primary pulmonary hypertension. Protein Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction [The Uniprot Consortium]