Anti-Human BANK1 Antibody Pair

Product Description: B cell scaffold protein with ankyrin repeats 1 (BANK1) is a crucial protein primarily expressed in B cells, where it plays significant roles in various signaling pathways, including B cell receptor (BCR) signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. It is encoded by the BANK1 gene located on chromosome 4 and contains several functional domains, including ankyrin repeat-like motifs and a coiled-coil domain. Genetic variants of BANK1 have been associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE), where certain polymorphisms influence its expression and functionality. BANK1 facilitates calcium mobilization in B cells and promotes Lyn-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors, highlighting its integral role in B cell activation and immune response modulation. Protein Function: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2 [The Uniprot Consortium]