Anti-Human BAG4 Antibody Pair

Product Description: BAG family molecular chaperone regulator 4 (BAG4) is a protein that functions as a co-chaperone, primarily involved in the regulation of cellular stress responses and protein homeostasis. It contains a BAG domain that interacts with heat shock proteins, particularly Hsp70, to modulate their activity and influence protein folding and degradation processes. BAG4 is known to inhibit apoptosis by interacting with various cell death-related proteins, including BCL-2 and tumor necrosis factor receptor (TNF-R1), thereby negatively regulating apoptosis signaling pathways. Dysregulation of BAG4 has been implicated in several diseases, elevated levels of BAG4 are associated with poor prognosis in malignancies such as breast cancer and multiple myeloma, where it may contribute to tumor cell survival and resistance to therapy. Additionally, BAG4's involvement in inflammatory responses suggests its potential role in autoimmune diseases. Protein Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria [The Uniprot Consortium]