Anti-Human UPF2 Antibody Pair

Product Description: UPF2 regulator of nonsense mediated mRNA decay (UPF2) is a key component of the nonsense-mediated mRNA decay (NMD) pathway, which serves as a quality control mechanism to eliminate mRNAs containing premature stop codons. UPF2 is part of a post-splicing multiprotein complex, interacting with UPF1 and UPF3 proteins, and plays a central role in the formation of the surveillance complex that recognizes and degrades faulty mRNAs. It acts as an adaptor between Stau1 and UPF1, stimulating UPF1's catalytic activity and facilitating mRNA nuclear export and surveillance. UPF2 is primarily located in the perinuclear region and is expressed in various tissues, including the brain, where it has been implicated in regulating synaptic spine density and neuronal plasticity. Alterations in UPF2 function can impact neural processes and behavior, suggesting a potential link to neurodevelopmental or neuropsychiatric conditions. Protein Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA [The Uniprot Consortium]