Anti-Human TNF Antibody Pair

Product Description: Tumor necrosis factor (TNF) is a cytokine that plays a crucial role in the body's immune response and inflammation. It is primarily produced by macrophages and other immune cells to fight off infections and promote tissue repair.However, excessive or prolonged production of TNF can lead to chronic inflammation and various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, and ankylosing spondylitis.TNF triggers the release of other inflammatory molecules, contributing to joint damage, cartilage destruction, and the painful symptoms associated with these conditions. While TNF is essential for immune defense, its dysregulation can drive pathogenic inflammation, making it a therapeutic target for managing autoimmune and inflammatory disorders through TNF inhibitors. Protein Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:16829952, PubMed:22517918, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity) , The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells [The Uniprot Consortium]