Anti-Human THPO Antibody Pair

Product Description: The THPO gene encodes thrombopoietin, a cytokine that is essential for the production and maturation of platelets from megakaryocytes in the bone marrow. Thrombopoietin stimulates megakaryocyte proliferation and differentiation, and its levels are inversely regulated by circulating platelets. Biallelic loss-of-function mutations in THPO cause severe thrombocytopenia and bone marrow failure (congenital amegakaryocytic thrombocytopenia-2, CAMT2). In contrast, monoallelic loss-of-function variants lead to reduced thrombopoietin secretion and autosomal-dominant thrombocytopenia without affecting other blood cell lineages. THPO binds to the MPL receptor on megakaryocytes, promoting their maturation and platelet formation. Genetic mutations in the THPO gene can lead to disorders such as essential thrombocythemia and congenital amegakaryocytic thrombocytopenia. Protein Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets [The Uniprot Consortium]