Anti-Human THBS4 Antibody Pair

Product Description: Thrombospondin 4 (THBS4) is a non-structural extracellular matrix protein encoded by the THBS4 gene, belonging to the thrombospondin family known for mediating cell-to-cell and cell-to-matrix interactions. THBS4 plays critical roles in tissue remodeling, angiogenesis, and cell proliferation, particularly in response to injury or stress. The protein forms a pentamer and binds calcium and heparin, facilitating its diverse functions in different tissues. Its unique properties differentiate it from other thrombospondins, contributing to both pro-angiogenic and pro-inflammatory processes in pathological contexts. It has been implicated in various diseases, notably cardiovascular conditions such as myocardial infarction, heart failure, and atherosclerosis, where its expression increases significantly during tissue damage and repair. Additionally, THBS4 is associated with cancer progression due to its ability to enhance cell migration and proliferation via pathways like AKT signaling. Protein Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity) [The Uniprot Consortium]