Anti-Human STX8 Antibody Pair

Product Description: Syntaxin 8 (STX8) is a member of the syntaxin family of proteins involved in intracellular vesicle trafficking, particularly mediating protein transport between early and late endosomes as well as retrograde transport from the Golgi to the endoplasmic reticulum. It contains three N-terminal helices, a SNARE domain, and a C-terminal transmembrane domain, and forms SNARE complexes with proteins such as syntaxin 7, vti1b, and endobrevin, playing a key role in homotypic fusion of late endosomes. STX8 also modulates the trafficking of specific proteins like the TrkA receptor and the potassium channel TASK-1 by influencing their surface expression through endosomal and post-biosynthetic pathways. In terms of disease relevance, alterations in STX8-mediated trafficking impact cellular functions such as receptor surface levels that can affect signaling, for example, defects in STX8 influence cellular transport processes critical in kidney function and immune cell cytotoxicity, linking STX8 dysfunction to pathologies involving vesicle trafficking and cellular transport disorders. Protein Function: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER [The Uniprot Consortium]