Anti-Human STAMBP Antibody Pair

Product Description: STAM-binding protein (STAMBP), also known as AMSH, is a deubiquitinating enzyme that plays a vital role in endosomal sorting and trafficking. It interacts with endosomal sorting complexes required for transport (ESCRTs), facilitating the removal of ubiquitin from target proteins, which is essential for maintaining protein homeostasis within cells. STAMBP's functions extend beyond protein degradation, it is involved in various signaling pathways, including those related to cell growth and angiogenesis. Dysregulation of STAMBP has been linked to several diseases. Notably, mutations in the STAMBP gene are associated with microcephaly-capillary malformation syndrome, characterized by developmental delays, seizures, and vascular abnormalities due to impaired protein degradation and signaling. Additionally, STAMBP has been implicated in cancer progression, particularly in triple-negative breast cancer (TNBC), where it promotes tumor growth by stabilizing the actin-binding protein RAI14 through deubiquitination. Protein Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699) [The Uniprot Consortium]