Anti-Human ST6GALNAC5 Antibody Pair

Product Description: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5) is a Golgi type II transmembrane glycosyltransferase enzyme consisting of 316 amino acids with a molecular mass of approximately 36.4 kDa. It catalyzes the transfer of sialic acid to cell surface proteins and is specifically involved in the biosynthesis of ganglioside GD1alpha from GM1b, predominantly expressed in brain tissue. ST6GALNAC5 modulates cell-cell interactions and influences receptor tyrosine kinases via membrane microdomain formation. Functionally, it plays a role in cell junction regulation, differentiation, and metastasis, particularly in prostate and breast cancers. Overexpression of ST6GALNAC5 promotes cancer cell invasion and proliferation by activating pathways such as MAPK/ERK1/2. Notably, it facilitates breast cancer brain metastasis by enabling cancer cells to cross the blood-brain barrier, while its role may vary depending on cancer context, sometimes inhibiting glioma invasiveness. Protein Function: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675) [The Uniprot Consortium]