Anti-Human SPRED2 Antibody Pair

Product Description: Sprouty related EVH1 domain containing 2 (SPRED2) is a crucial member of the SPRED protein family, characterized by its three functional domains: the N-terminal EVH1 domain, the central c-Kit-binding domain, and the C-terminal Sprouty-related domain. SPRED2 primarily functions as a negative regulator of the MAPK signaling pathway, inhibiting cell proliferation and differentiation in response to growth factors. Its expression is vital in various tissues, particularly in the lungs, where it plays a significant role in managing inflammatory responses and tissue repair processes. Dysregulation of SPRED2 has been linked to several diseases, including pulmonary fibrosis, asthma, and other inflammatory conditions, where its reduced expression can exacerbate disease progression by enhancing epithelial cell proliferation and inflammatory responses. The protein's properties include its ability to form dimers and interact with other signaling molecules, which are essential for its regulatory functions in cellular signaling pathways. Protein Function: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity) [The Uniprot Consortium]