Anti-Human SLURP1 Antibody Pair

Product Description: SLURP1 (Secreted Ly6/uPAR-related protein 1) is an immunomodulatory protein that plays important roles in skin development, inflammation regulation, and cancer suppression. It acts primarily by binding to nicotinic acetylcholine receptors, especially alpha7-nAChR, as well as other receptors like EGFR and PDGFRalpha. SLURP1 inhibits neutrophil adhesion and migration, suppresses pro-inflammatory cytokine production, and modulates keratinocyte differentiation. Mutations in the SLURP1 gene cause Mal de Meleda, a rare autosomal recessive skin disorder characterized by palmoplantar keratoderma. In cancer, SLURP1 demonstrates antiproliferative and anti-migration effects on lung adenocarcinoma cells by downregulating the PI3K/AKT/mTOR signaling pathway. Additionally, SLURP1 has been shown to prevent inflammation-induced proliferation in intestinal epithelial cells by modulating NF-kappaB expression and reversing LPS-induced inflammatory responses. Protein Function: Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation, the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896) [The Uniprot Consortium]