Anti-Human SEMA6D Antibody Pair

Product Description: Semaphorin 6D (SEMA6D) is a type I transmembrane glycoprotein belonging to the class 6 semaphorin family, distinguished by a cysteine-rich sema domain essential for its functional specificity. This protein plays a critical role as an axon guidance molecule, showing growth cone-collapsing activity on dorsal root ganglion neurons and acting as a stop signal in target areas. SEMA6D preferentially binds to class A plexin receptors, especially Plexin-A1, guiding neuronal development, influencing cardiac morphogenesis, and mediating immune cell interactions such as those between dendritic cells and T cells. Its expression is highest in brain, kidney, placenta, and heart, with multiple isoforms regulated via alternative splicing. Beyond nervous system guidance, SEMA6D contributes to immune regulation by influencing late-phase T cell activity. Clinically, altered SEMA6D expression has been associated with several diseases, including gastric cancer, where it promotes tumor angiogenesis and progression, and shows links to autism spectrum disorder and inflammatory bowel disease. Protein Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity) [The Uniprot Consortium]