Anti-Human SBNO1 Antibody Pair

Product Description: Strawberry notch homolog 1 (SBNO1) is a nuclear protein and member of the SF2 family, which includes DExD/H box helicases and Swi2/Snf2 chromatin remodelers, and is predicted to enable chromatin DNA and histone binding activities. SBNO1 plays a key role in transcriptional regulation, particularly by stimulating the activity of transcription factors such as Yap/Tead4 and Notch/Rbpj, and is essential for the activation of specific gene enhancers like Cdx2 during early embryonic development. It is involved in the regulation of neural stem cell proliferation, enhancing GSK3B phosphorylation through the PI3K-Akt signaling pathway, and is exclusively localized in the nucleus throughout development. Disruption of SBNO1 in mouse models leads to embryonic arrest at the preimplantation stage due to loss of trophectoderm-specific gene expression, highlighting its critical developmental role, in humans, altered SBNO1 expression has been observed in glioblastoma, suggesting a potential link to disease. Protein Function: Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation [The Uniprot Consortium]