Anti-Human RGS9 Antibody Pair

Product Description: Regulator of G protein signaling 9 (RGS9), encoded by the RGS9 gene, is a GTPase-activating protein (GAP) that accelerates the deactivation of G protein-coupled receptor (GPCR) signaling by enhancing GTP hydrolysis on Galpha subunits, thereby terminating downstream signals. It exists in two isoforms: RGS9-1, primarily localized in retinal photoreceptors, and RGS9-2, expressed in the striatum and other brain regions. RGS9 forms obligate complexes with the Gbeta5 subunit, which stabilizes the protein, and interacts with tissue-specific partners like R9AP in the retina to regulate phototransduction. In the brain, RGS9-2 modulates dopamine and opioid receptor signaling, influencing neuronal plasticity and reward pathways. Mutations in RGS9 are linked to bradyopsia, a rare retinal disorder characterized by delayed dark adaptation and reduced light sensitivity due to impaired phototransduction kinetics. Protein Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction, key element in the recovery phase of visual transduction (By similarity) [The Uniprot Consortium]