Anti-Human RALGAPA1 Antibody Pair

Product Description: Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1) is a key component of the RalGAP complex, which regulates the activity of RalA and RalB, small GTPases involved in intracellular vesicle trafficking, cell migration, and cytoskeletal dynamics. This protein exhibits GTPase activator activity, converting Ral proteins from their active GTP-bound state to an inactive GDP-bound form. RALGAPA1 functions as the catalytic subunit of the heterodimeric RalGAP complex, alongside a scaffolding beta subunit, and plays a crucial role in maintaining cellular signaling balance. Dysregulation of RALGAPA1 can lead to constitutive activation of RalA, disrupting processes such as neuronal polarity and brain development. Mutations or deficiencies in RALGAPA1 are associated with profound neurodevelopmental disabilities, muscular hypotonia, infantile spasms, and feeding abnormalities. Additionally, reduced expression of RALGAPA1 has been linked to enhanced malignancy in cancers like pancreatic ductal adenocarcinoma due to increased migratory and invasive capacities of tumor cells. Protein Function: Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB [The Uniprot Consortium]