Anti-Human RALB Antibody Pair

Product Description: Ras-related protein Ral-B (RALB) is a small GTPase that belongs to the RAS superfamily of proteins, which act as molecular switches in various cellular processes. RALB is primarily involved in regulating vesicle trafficking, cell migration, and cytoskeletal dynamics. It cycles between an active GTP-bound state and an inactive GDP-bound state, facilitating interactions with downstream effectors that mediate these functions. RALB has been shown to play a significant role in cancer biology, where its overexpression is associated with enhanced tumor cell survival, invasion, and metastasis. For instance, RALB has been implicated in the progression of breast cancer and other malignancies by promoting epithelial-mesenchymal transition (EMT) and influencing signaling pathways related to cell proliferation. Additionally, dysregulation of RALB has been linked to other diseases, including neurodegenerative disorders. Protein Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179) [The Uniprot Consortium]