Anti-Human pTau217 Antibody Pair

Product Description: Plasma p-tau217 is a biomarker associated with Alzheimer's disease (AD) pathology. Research has shown that plasma p-tau217 is a sensitive marker of the clinical manifestation and progression of AD, including amyloid accumulation, tau burden, brain atrophy, and physical degradation. It has been found to be a potential non-invasive biomarker of AD, with high diagnostic accuracy in differentiating AD from other neurodegenerative diseases. Plasma p-tau217 has also been associated with longitudinal increases in Abeta PET uptake and cognitive decline in Abeta-positive clinically unimpaired individuals. Additionally, higher baseline p-tau217 levels have been linked to greater future tau PET pathology burden and worse future memory performance. These findings suggest that plasma p-tau217 could serve as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials. Protein Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization [The Uniprot Consortium]