Anti-Human PREB Antibody Pair

Product Description: Prolactin regulatory element binding (PREB) protein is a transcription factor that plays a crucial role in regulating prolactin (PRL) gene expression. It specifically binds to a Pit1-binding element of the PRL promoter and is involved in the homeostatic regulation of PRL promoter activity. PREB contains two PQ-rich potential transactivation domains but lacks a discernible DNA-binding motif, exhibiting sequence-specific binding to the PRL promoter site 1P. Beyond its role in pituitary function, PREB has been implicated in the regulation of hepatic glucose metabolism, acting as a negative regulator of liver gluconeogenic genes by directly binding to their promoters at a prolactin core-binding element (PCBE). This suggests that PREB may play a broader role in metabolic regulation, potentially contributing to the pathogenesis of metabolic syndrome, obesity, and type-2 diabetes mellitus. Protein Function: Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:32358066). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:32358066) , Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription [The Uniprot Consortium]