Anti-Human PPM1B Antibody Pair

Product Description: Protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B) is a serine/threonine phosphatase with broad specificity. It dephosphorylates various proteins, including CDK2, CDK6, PRKAA1, PRKAA2, and TBK1, thereby regulating cellular processes such as cell cycle progression and antiviral signaling. PPM1B also plays a crucial role in terminating TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB. Additionally, it has been shown to inhibit DYRK1A kinase through dephosphorylation, which reduces tau oligomerization and aggregation, suggesting a potential role in neurodegenerative diseases like Alzheimer's disease. PPM1B is associated with various diseases, including Alzheimer's disease and Down syndrome, highlighting its importance in maintaining cellular homeostasis. Protein Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB [The Uniprot Consortium]