Anti-Human PON1 Antibody Pair

Product Description: Serum paraoxonase/arylesterase 1 (PON1) is a calcium-dependent enzyme that is primarily associated with high-density lipoproteins (HDL) and plays a significant role in lipid metabolism and antioxidant defense. It is involved in the hydrolysis of various substrates, including organophosphates and oxidized lipids, contributing to its atheroprotective properties by preventing the accumulation of oxidized low-density lipoprotein (LDL) cholesterol. Variations in the PON1 gene, particularly polymorphisms such as Q192R and L55M, can significantly affect enzyme activity and serum levels, influencing individual susceptibility to cardiovascular diseases. Low PON1 activity has been linked to an increased risk of atherosclerosis, diabetes, and neurodegenerative diseases. Protein Function: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation [The Uniprot Consortium]