Anti-Human PLEKHO2 Antibody Pair

Product Description: Pleckstrin homology domain containing O2 (PLEKHO2) is a protein characterized by the presence of a pleckstrin homology (PH) domain, which typically mediates interactions with phosphoinositides and proteins, facilitating membrane localization and signal transduction. PLEKHO2 is involved in cellular processes such as cytoskeletal organization, cell migration, and innate immune responses, with functional associations in pathways like the MAPK signaling cascade. It is expressed in various tissues and participates in protein-protein interactions critical for cell signaling and apoptosis regulation. Disease-wise, PLEKHO2 has been implicated in cancer progression, notably colorectal cancer, where the miR-106b/NR2F2-AS1/PLEKHO2 axis regulates tumor cell migration and invasion through the MAPK pathway. Its dysregulation may contribute to tumor metastasis.