Anti-Human PFDN2 Antibody Pair

Product Description: Prefoldin subunit 2 (PFDN2) is one of six subunits of the prefoldin molecular chaperone complex in humans. This protein binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it, playing a crucial role in binding to nascent polypeptide chains and promoting proper protein folding. PFDN2 helps stabilize newly synthesized polypeptides, preventing misfolding and aggregation. The prefoldin complex has a distinctive jellyfish-shaped structure where the six subunits form long coiled coils attached to a central structure. PFDN2 has been implicated in protecting neuronal cells from polyglutamine toxicity by preventing aggregation formation. Studies have shown that knockdown of PFDN2 in undifferentiated neuronal cells increases the formation of aggregates of polyQ stretches and polyQ-expanded huntingtin (HTT), which are associated with Huntington's disease. Importantly, overexpression of prefoldin has been observed to reduce the aggregated form of pathogenic huntingtin. Protein Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins [The Uniprot Consortium]