Anti-Human Peroxiredoxin-6 Antibody Pair

Product Description: Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme that plays a crucial role in protecting cells from oxidative stress. It is a member of the peroxiredoxin family of antioxidant enzymes and is widely distributed in various organs, particularly in the lungs. PRDX6 has two distinct active sites, enabling it to reduce hydrogen peroxide (H2O2) and short-chain organic, fatty acid, and phospholipid hydroperoxides, thereby protecting cells from oxidative injury. It also exhibits phospholipase A2 (PLA2) activity, which is essential for the repair of peroxidized cell membranes and the regulation of phospholipid turnover. PRDX6 has been implicated in various diseases, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, where its PLA2 activity can either protect against or exacerbate oxidative stress depending on the context. Overall, PRDX6 is a critical enzyme for maintaining cellular redox balance and preventing oxidative damage. Protein Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860) [The Uniprot Consortium]