Anti-Human PALM2AKAP2 Antibody Pair

Product Description: PALM2 and AKAP2 fusion (PALM2AKAP2) is a naturally occurring readthrough transcript producing a fusion protein combining paralemmin-2 (PALM2) and A-kinase anchoring protein 2 (AKAP2). It belongs to the paralemmin downstream gene (PDG) family and is characterized by binding to the regulatory subunit (RII) of protein kinase A (PKA). This fusion protein may play roles in establishing cell polarity and integrating PKA-RII isoforms within signaling systems, suggesting involvement in neuronal and cardiac signaling pathways. Functionally, AKAP2 anchors extracellular signal-regulated kinase 1 (ERK1), regulating cardiac myofibroblast migration, which may influence cardiac remodeling processes. Its participation in cardiac beta-adrenergic signaling and regulation of cardiac cell migration implies potential relevance in cardiovascular diseases. Protein Function: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton [The Uniprot Consortium]