Anti-Human Palladin Antibody Pair

Product Description: Palladin, cytoskeletal associated protein (PALLD) is a cytoskeletal protein crucial for organizing the actin cytoskeleton, influencing cell shape, motility, and adhesion. It exists in various isoforms due to alternative splicing and is predominantly expressed in mesenchymal cells. Mutations in PALLD are linked to familial pancreatic cancer, with specific mutations like P239S associated with increased cell migration and invasive potential in cancer cells. Overexpression of palladin has also been observed in pancreatic neoplasia, suggesting its role in tumor microenvironment alterations rather than directly within cancer cells themselves. Additionally, PALLD mutations have been implicated in other diseases, including dilated cardiomyopathy and myocardial infarction, highlighting its significance beyond cancer biology. Protein Function: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci [The Uniprot Consortium]