Anti-Human OSCAR Antibody Pair

Product Description: Osteoclast-associated immunoglobulin-like receptor (OSCAR) is a type I transmembrane protein primarily expressed on osteoclasts and some immune cells, playing a vital role in bone remodeling and immune regulation. Belonging to the immunoglobulin superfamily, OSCAR functions as a receptor that enhances osteoclast differentiation and activity through its interaction with specific ligands, which promotes bone resorption. It is particularly important in maintaining bone homeostasis by mediating the effects of cytokines and other signaling molecules involved in osteoclastogenesis. Additionally, OSCAR is implicated in the regulation of immune responses, influencing the interplay between bone and immune systems. Dysregulation of OSCAR expression or function can lead to various pathological conditions, including osteoporosis, where excessive osteoclast activity results in bone loss. Furthermore, it has been associated with inflammatory diseases such as rheumatoid arthritis, where increased OSCAR signaling contributes to joint destruction. Protein Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation [The Uniprot Consortium]