Anti-Human NXPH3 Antibody Pair

Product Description: Neurexophilin 3 (NXPH3) is a secreted neuronal glycoprotein that functions as a specific ligand for presynaptic alpha-neurexins, forming a tight extracellular complex essential for efficient neurotransmitter release. Structurally, NXPH3 contains a signal peptide and mature peptide region and is localized mainly in select neuronal populations such as subplate-derived neurons in cortical layer 6b, granule cells in the vestibulocerebellum, and Cajal-Retzius cells during development. Its expression pattern suggests a modulatory role in synaptic function rather than a universal cofactor for alpha-neurexins. Functional studies in knockout mice revealed that loss of NXPH3 leads to sensory processing deficits and impaired motor coordination without gross anatomical brain defects, indicating its importance in specific neuronal circuits involved in sensorimotor gating. Clinically, mutations or dysregulation of NXPH3 have been linked to neurodevelopmental disorders such as lissencephaly with complex brainstem malformations and Sjogren-Larsson syndrome. Protein Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) [The Uniprot Consortium]