Anti-Human NPPC Antibody Pair

Product Description: Natriuretic peptide C (NPPC), also known as C-type natriuretic peptide (CNP), is a protein encoded by the NPPC gene in humans. It is part of the natriuretic peptide family, which includes atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Unlike ANP and BNP, CNP does not have direct natriuretic activity but instead acts as a selective agonist for the B-type natriuretic receptor (NPRB). CNP is synthesized and secreted from the endothelium in response to stimuli such as shear stress and proinflammatory cytokines. It plays a crucial role in endochondral ossification by regulating cartilaginous growth plate chondrocytes' proliferation and differentiation. CNP is also implicated in various physiological processes, including body fluid homeostasis and blood pressure control, and has been studied for its roles in reproduction, pregnancy, and fetal development. Protein Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed:1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034). Binds the clearance receptor NPR3 (PubMed:11533490) [The Uniprot Consortium]