Anti-Human NEFL Antibody Pair

Product Description: NEFL encodes the light chain of neurofilaments, which are structural proteins that maintain the caliber of neuronal axons. Mutations in the NEFL gene can lead to Charcot-Marie-Tooth disease types 1F and 2E, which are disorders of the peripheral nervous system characterized by neuropathies.Disturbances in the metabolism and localization of NEFL, as well as mutations in the NEFL gene, have been implicated in the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), and Huntington's disease. NEFL can be released from damaged neurons and elevated levels of NEFL in the cerebrospinal fluid and blood have been reported as a biomarker for neuronal injury in these conditions. The detection of NEFL has potential applications in disease diagnosis, prognosis, and monitoring of therapeutic treatments. Protein Function: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity) [The Uniprot Consortium]