Anti-Human MTFR1L Antibody Pair

Product Description: Mitochondrial fission regulator 1 like (MTFR1L) is a protein that plays a crucial role in regulating mitochondrial morphology and dynamics. It is localized to the outer mitochondrial membrane and is involved in the adaptation of mitochondrial dynamics to metabolic changes. MTFR1L is phosphorylated by AMP-activated protein kinase (AMPK), which controls its function in regulating mitochondrial morphology, including mitochondrial fission and fusion events. Loss of MTFR1L leads to mitochondrial elongation and increased mitochondrial fusion events, suggesting its importance in maintaining mitochondrial homeostasis. While there is no direct association with specific diseases, alterations in MTFR1L expression have been observed in response to various chemical exposures, such as bisphenol A and carbon nanotubes, which may have implications for cellular health. Protein Function: Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels [The Uniprot Consortium]