Anti-Human METTL2A Antibody Pair

Product Description: Methyltransferase 2A, tRNA N3-cytidine (METTL2A) is a key enzyme involved in the methylation of tRNA, specifically catalyzing the N3-methylcytidine modification at position 32 of the tRNA anticodon loop, which is crucial for proper tRNA function and protein synthesis. Located on chromosome 17, METTL2A has been implicated in various cancers, with studies showing its overexpression in several tumor types including breast and lung cancers, suggesting a potential role as an oncogene. The enzyme's specificity and recognition of tRNA substrates are influenced by sequence motifs within the anticodon loop and modified nucleotides at position 37. Protein Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557) [The Uniprot Consortium]