Anti-Human MAEA Antibody Pair

Product Description: Macrophage erythroblast attacher, E3 ubiquitin ligase (MAEA) is a multifunctional protein that serves as a core component of the CTLH E3 ubiquitin-protein ligase complex, selectively accepting ubiquitin from UBE2H to mediate ubiquitination and subsequent proteasomal degradation of transcription factor HBP1. MAEA plays a crucial role in erythropoiesis by mediating the attachment of erythroblasts to macrophages, promoting terminal maturation and enucleation of erythrocytes while inhibiting erythroid cell apoptosis. It participates in erythroblastic island formation, the functional unit of definitive erythropoiesis, and associates with F-actin to regulate actin distribution in erythroblasts and macrophages. Recent studies have shown MAEA is essential for hematopoietic stem cell (HSC) maintenance and lymphoid potential, with its deletion in mice severely impairing HSC quiescence and leading to a lethal myeloproliferative syndrome. MAEA has been associated with several diseases including type 2 diabetes mellitus, various hemoglobinopathies (hemoglobin D and E diseases), hereditary elliptocytosis, myelofibrosis, and cancer. Protein Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages, this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable) [The Uniprot Consortium]