Anti-Human LRRC4 Antibody Pair

Product Description: Leucine rich repeat containing protein 4 (LRRC4), also known as netrin-G ligand 2 (NGL-2), is a synaptic adhesion protein highly expressed in the brain. It plays a crucial role in regulating the formation of excitatory synapses by recruiting pre- and post-synaptic proteins. LRRC4 is a member of the partitioning-defective protein (PAR) polarity complex, promoting axon differentiation and mediating synaptic plasticity. It contains extracellular leucine-rich repeat domains, an immunoglobulin C2 domain, a transmembrane domain, and a PDZ-binding domain in the cytoplasm. LRRC4 is involved in organizing lamina-specific dendrite differentiation and auditory synaptic responses. In terms of disease associations, LRRC4 has been identified as a candidate susceptibility gene for autism and a neuroprotective factor in spinal nerve damage. Additionally, it functions as a tumor suppressor gene in gliomas, with its expression negatively correlated with glioma malignancy. Protein Function: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity) [The Uniprot Consortium]