Anti-Human Liver Carboxylesterase 1 Antibody Pair

Product Description: Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases responsible for the hydrolysis of ester and amide bonds. It has broad substrate specificity, ranging from small molecule esters to long chain fatty acid esters and thioesters, and plays a major role in the pharmacokinetic behavior of therapeutic agents containing ester bonds. The protein is expressed in various tissues, including the liver, and its deficiency can lead to altered drug metabolism. CES1 is involved in the detoxification of drugs such as cocaine and heroin in serum and liver, and it can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents. Deficiency in CES1 has been associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Protein Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:18762277, PubMed:7980644, PubMed:9169443, PubMed:9490062). Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:18762277, PubMed:7980644, PubMed:9169443, PubMed:9490062). Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644). Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644). Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:11015575, PubMed:16024911, PubMed:16971496, PubMed:18762277). First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:16971496, PubMed:18599737, PubMed:18762277) [The Uniprot Consortium]