Anti-Human LIMA1 Antibody Pair

Product Description: LIM domain and actin binding 1 (LIMA1), also known as EPLIN or SREBP3, is a cytoskeleton-associated protein that plays a crucial role in regulating actin filament dynamics. It contains a central LIM domain and multiple actin-binding domains at its ends, enabling it to cross-link and stabilize actin filaments, increase the number and size of actin stress fibers, and inhibit actin filament depolymerization and membrane ruffling. LIMA1 exists in two isoforms, LIMA1-alpha and LIMA1-beta, and can dimerize or interact with other proteins via its LIM domain. By stabilizing the actin network and inhibiting Arp2/3-mediated actin nucleation, LIMA1 is essential for maintaining cytoskeletal integrity and cadherin-mediated cell adhesion. Loss or deficiency of LIMA1 disrupts cytoskeletal dynamics, cell motility, and cell-cell adhesion, which can enhance tumor cell proliferation, invasion, and migration. Protein Function: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity) [The Uniprot Consortium]