Anti-Human LEFTY2 Antibody Pair

Product Description: Left-right determination factor 2 (LEFTY2), also known as TGFB4 or Endometrial Bleeding-Associated Factor, is a secreted protein belonging to the TGF-beta cytokine family, with a molecular weight of approximately 39.1 kDa. LEFTY2 is produced as a recombinant protein in mammalian systems, typically spanning residues Phe78-Pro366, and is characterized by high purity and low endotoxin levels in research applications. Functionally, LEFTY2 plays a crucial role in establishing left-right asymmetry during embryonic development, particularly influencing the patterning of organ systems such as the heart and lungs across vertebrates. Mutations or dysregulation of LEFTY2 are associated with congenital left-right axis malformations, especially affecting the heart and lungs, and abnormal expression has also been linked to certain infertility cases and endometrial bleeding disorders. Protein Function: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding [The Uniprot Consortium]