Anti-Human LAT2 Antibody Pair

Product Description: Linker for activation of T-cells family member 2 (LAT2) is a member of the LAT protein family, which plays a crucial role in T-cell activation and signaling. LAT2 acts as an adaptor protein that facilitates the assembly of signaling complexes following T-cell receptor engagement, thereby promoting downstream signaling pathways essential for T-cell proliferation and differentiation. It is expressed in various tissues, including immune cells, and is involved in processes such as cell adhesion and migration. Dysregulation of LAT2 has been implicated in several diseases, particularly autoimmune disorders and cancers. For instance, altered LAT2 expression can contribute to the pathogenesis of conditions like rheumatoid arthritis and systemic lupus erythematosus by affecting immune cell signaling and function. Additionally, LAT2 has been associated with tumor progression in cancers such as leukemia and lymphoma, where its signaling pathways may promote cell survival and proliferation. Protein Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2 [The Uniprot Consortium]