Anti-Human LAMP3 Antibody Pair

Product Description: Lysosomal-associated membrane protein 3 (LAMP3), also known as DC-LAMP, is a type I integral membrane protein encoded by the LAMP3 gene in humans. This protein is primarily expressed in mature dendritic cells and plays a crucial role in antigen processing and immune responses. Structurally, LAMP3 consists of approximately 416 amino acids, with most of the protein localized within lysosomes. It has been implicated in various diseases, including mumps and REM sleep behavior disorder, and is associated with the maturation of dendritic cells, enhancing their ability to present antigens to T-cells. Additionally, LAMP3 is involved in the inhibition of viral replication, particularly for Influenza A and mumps viruses, by facilitating key steps in their life cycles. Its expression is notably high during human fetal development, especially in lung tissue. Protein Function: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752) , (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection , (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F , (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium [The Uniprot Consortium]