Anti-Human L1CAM Antibody Pair

Product Description: L1 cell adhesion molecule (L1CAM) is a critical transmembrane glycoprotein involved in neuronal development, promoting cell adhesion, migration, and neurite outgrowth. It consists of six immunoglobulin-like domains and five fibronectin type III domains, facilitating both homophilic and heterophilic interactions essential for neuronal connectivity and myelination processes. L1CAM's dysregulation is implicated in various cancers, including ovarian and gastric cancers, where its overexpression correlates with enhanced cell proliferation, invasion, and metastasis, marking it as a potential biomarker for aggressive tumors. In contrast, mutations in the L1CAM gene lead to L1 syndrome (CRASH), characterized by neurological disorders such as corpus callosum hypoplasia and spastic paraplegia, predominantly affecting males. Protein Function: Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity [The Uniprot Consortium]