Anti-Human IRAG2 Antibody Pair

Product Description: Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2), also known as Jaw1 or lymphoid-restricted membrane protein (LRMP), is a type II membrane protein that plays a crucial role in intracellular calcium signaling. It is primarily localized to the endoplasmic reticulum and interacts with inositol 1,4,5-triphosphate receptors (IP3Rs), modulating calcium release from intracellular stores. IRAG2 is expressed in various tissues, including immune cells and the pancreas, where it influences processes such as platelet aggregation and exocrine pancreatic function. Dysregulation of IRAG2 has been implicated in several diseases, particularly in cancer and immune disorders. For instance, altered expression of IRAG2 may affect immune cell function and contribute to autoimmune diseases. In cancer, its role as a modulator of calcium signaling suggests that changes in IRAG2 expression could influence tumor growth and metastasis. Protein Function: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules, this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity) [The Uniprot Consortium]