Anti-Human IL32 Antibody Pair

Product Description: Interleukin-32 (IL-32) is a pro-inflammatory cytokine that plays a crucial role in immune regulation and inflammation. It exists in multiple isoforms generated by alternative splicing, with IL-32gamma being the largest and most potent in inducing inflammatory responses. IL-32 lacks a typical signal peptide for secretion, but it can be released extracellularly, potentially through cell death or other mechanisms. The cytokine acts by inducing the production of other pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1beta. Dysregulation of IL-32 has been linked to various inflammatory and autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease, where it contributes to disease pathogenesis by sustaining inflammation. Despite its pro-inflammatory role, IL-32 may also exhibit anti-inflammatory properties in certain contexts, as demonstrated in a murine model of allergic asthma. Protein Function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK [The Uniprot Consortium]