Anti-Human IL15 Antibody Pair

Product Description: Interleukin-15 (IL-15) is a pleiotropic cytokine that plays a crucial role in regulating both innate and adaptive immune responses. It is involved in the development, proliferation, survival, and differentiation of various immune cells, including natural killer (NK) cells, T cells, and B cells. Dysregulation of IL-15 expression has been implicated in several autoimmune and chronic inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, psoriasis, systemic lupus erythematosus, and inflammatory bowel disease. In these conditions, increased levels of IL-15 and its receptor (IL-15Ralpha) contribute to the maintenance of self-reactive memory T cells, bystander activation of inflammatory cells, and upregulation of activating receptors on T cells. Conversely, in some infectious diseases, IL-15 production may be compromised, and exogenous administration of IL-15 can potentially enhance immune responses against pathogens. Protein Function: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8178155, PubMed:9326248). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (PubMed:9326248). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits (PubMed:10233906, PubMed:23104097, PubMed:8026467). Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (PubMed:7568001). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity) [The Uniprot Consortium]