Anti-Human ICAM2 Antibody Pair

Product Description: Intercellular adhesion molecule 2 (ICAM2), also known as CD102, is a type I transmembrane glycoprotein belonging to the ICAM family, characterized by two immunoglobulin-like C2-type domains and primarily expressed on endothelial cells and some leukocytes. ICAM2 plays a crucial role in mediating adhesive interactions important for immune surveillance, including lymphocyte recirculation, antigen-specific immune responses, and NK cell-mediated clearance, by binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also regulates spermatid adhesion on Sertoli cells, contributing to spermatogenesis. Beyond its physiological roles, ICAM2 has been implicated in disease contexts, it can suppress metastatic phenotypes in tumor cells by linking membrane proteins to the actin cytoskeleton, thereby impacting tumor cell motility and metastatic potential. Protein Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance [The Uniprot Consortium]