Anti-Human ICA1 Antibody Pair

Product Description: Islet cell autoantigen 1 (ICA1) is a protein encoded by the ICA1 gene, which is primarily expressed in pancreatic islet cells and plays a significant role in autoimmune responses. This protein contains an arfaptin homology domain, enabling it to participate in membrane trafficking and protein interactions within the Golgi complex and immature secretory granules. ICA1 is recognized as an autoantigen, particularly in insulin-dependent diabetes mellitus (Type 1 diabetes), where it can trigger an immune response that leads to the destruction of insulin-producing beta cells in the pancreas. Additionally, ICA1 has been implicated in primary Sjögren's syndrome, an autoimmune disorder characterized by dry mouth and eyes due to the immune-mediated damage of exocrine glands. Variations in the expression of ICA1 can influence susceptibility to these diseases, with certain polymorphisms associated with altered immune responses. Protein Function: May play a role in neurotransmitter secretion [The Uniprot Consortium]