Anti-Human HBEGF Antibody Pair

Product Description: Proheparin-binding EGF-like growth factor (HBEGF) is a member of the epidermal growth factor (EGF) family, synthesized as a membrane-anchored glycoprotein that plays critical roles in cellular processes such as proliferation, differentiation, and wound healing. HBEGF can be cleaved to release a soluble form that exhibits mitogenic and chemotactic properties, particularly for smooth muscle cells and fibroblasts. Its expression is highly regulated and occurs in response to various stimuli, including inflammation and tissue injury. Dysregulation of HBEGF has been implicated in several diseases: Elevated levels of HBEGF have been found in various malignancies, including breast, lung, and colorectal cancers. Additionally, HBEGF is involved in cardiovascular diseases, particularly in cardiac hypertrophy and atherosclerosis, where it mediates vascular remodeling. Protein Function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor [The Uniprot Consortium]