Anti-Human HAGH Antibody Pair

Product Description: Hydroxyacylglutathione hydrolase (HAGH), also known as glyoxalase II, is an enzyme encoded by the HAGH gene in humans, located on chromosome 16. It plays a critical role in the detoxification of reactive carbonyl compounds by catalyzing the hydrolysis of S-(2-hydroxyacyl)glutathione to produce glutathione and a 2-hydroxy carboxylate, thus participating in pyruvate metabolism and cellular defense mechanisms against oxidative stress. HAGH is associated with various diseases, particularly neurodegenerative conditions like Alzheimer's disease, where its protein levels have been found to correlate with disease risk in certain genetic backgrounds. Mutations or dysregulation in HAGH activity can contribute to metabolic disorders and complications related to oxidative stress, emphasizing its importance in maintaining cellular homeostasis and preventing disease progression. Protein Function: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid [The Uniprot Consortium]