Anti-Human GLI2 Antibody Pair

Product Description: GLI family zinc finger 2 (GLI2) is a transcription factor belonging to the GLI family of zinc finger proteins. It functions as a mediator of Sonic hedgehog (Shh) signaling and plays crucial roles in embryonic development and cell fate determination. GLI2 contains DNA-binding zinc finger motifs, a repressor domain at the N-terminus, and an activator domain at the C-terminus. It can act as both a transcriptional activator and repressor, with its activity regulated through post-translational modifications and protein-protein interactions. GLI2 localizes to the cytoplasm and nucleus, where it regulates target gene expression involved in proliferation, survival, and differentiation. Mutations in GLI2 are associated with holoprosencephaly, a disorder of forebrain development, as well as pituitary anomalies and polydactyly. GLI2 dysregulation has also been implicated in various cancers, including medulloblastoma and basal cell carcinoma. Protein Function: Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856) , Involved in the smoothened (SHH) signaling pathway , Involved in the smoothened (SHH) signaling pathway , Involved in the smoothened (SHH) signaling pathway , Involved in the smoothened (SHH) signaling pathway , Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682) , (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682) , (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682) , (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682) , Acts as a transcriptional repressor [The Uniprot Consortium]