Anti-Human FUCA1 Antibody Pair

Product Description: Alpha-L-fucosidase 1 (FUCA1) is an enzyme encoded by the FUCA1 gene, playing a crucial role in the hydrolysis of fucose residues from glycoproteins and glycolipids. It belongs to the glycoside hydrolase family and adopts a (beta/alpha)8-barrel fold typical of GH29 enzymes, with its active site located at the core of the barrel. FUCA1's activity is essential for maintaining proper glycan degradation and remodeling, which are vital for cellular communication and immune responses. Structural studies have revealed its specificity for alpha(1,2)-, alpha(1,3)-, alpha(1,4)-, and alpha(1,6)-fucosylated linkages, highlighting its modular organization and catalytic efficiency. Mutations or deficiencies in FUCA1 lead to fucosidosis, a rare lysosomal storage disorder characterized by progressive neurological degeneration, growth retardation, and skeletal abnormalities due to impaired fucose metabolism. Reduced FUCA1 expression has also been implicated in colorectal tumors. Protein Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins [The Uniprot Consortium]